This plant may be known by one or more common names in. A histopathological study of the liver further suggest the hepatoprotective efficacy of eclipta alba extracts fig. Methanolic extract and active principle compound of a well known indian hepatoprotective herb, eclipta alba was tested for in vitro antimicrobial studies. This plant may be known by one or more common names in different places, and some are listed above. Hepatoprotective effect of eclipta alba leaves has been seen in paracetamol induced liver toxicity in rats prabu et al. Hepatoprotective activity of eclipta alba pdf indian j physiol pharmacol. The observations of these dose, clearly indicat the involvement of heptoprotective active principles in eclipta alba. It is used in medicines of pediatric conditions and in lactating mothers. The alcoholic extract has shown antiviral activity against ranikhet disease virus. Withania somnifera and eclipta alba ameliorate oxidative. Effect of aegle marmelos and eclipta alba leaves extract on the leaves of aegle marmelos and eclipta alba.
There are three kinds or eclipta albathe whiteflowering, the yellowflowering, and the blackfruiting, but all three grow throughout india by marshes, rivers, and. Hepatoprotective role of eclipta alba against high fatty diet. Comparative study on hepatoprotective activity of aegle marmelos and eclipta alba against alcohol induced in albino rats arun. The present study deals with hepatoprotective activity observed with ethanolic extracts of plant leaves and leaf callus of eclipta alba l. Dnadamaging steroidal alkaloids from eclipta alba from.
Collect 250 ml of eclipta alba leaves juice, 50 ml of amla juice, 50 ml of garlic juice and mix them. Alcoholic extract of eclipta alba shows in vitro antioxidant. Mode of antibacterial activity of eclalbasaponin isolated from eclipta alba. The liver is often abused by environmental toxins, which are eating habits, alcohol and overdose of certain drugs which can damage and weaken the liver and eventually lead to many diseases. Evaluation of hepatoprotective activity of amoora rohituka. The protective effect of the plant against carbon tetrachlorideinduced acute liver damage has been reported 3.
Antihyperglycemic activity of eclipta alba leaf on alloxaninduced diabetic rats j ananthi et al yale journal of biology and medicine 76 2003, pp. Eclipta alba false daisy is a herb that has traditionally been used in ayurvedic medicine for being a liver tonic for which it is one of the more effective herbs apparently and having beneficial effects on diabetes, eye health, and hair growth in regards to these claims, it appears to have some antidiabetic effects in animal studies with the mechanism of action not yet known. Among the two plants aegle marmelos has slightly high activity as compare to eclipta alba. Andrographis paniculata, eclipta alba, picrorrhiza kurroa, silibum marianum, phyllanthus and trichopus zeylanicus, etc. The present study was designed to compare the probable hepatoprotective activity of olive oil and n. The fresh plant is used as self medication by aids. This plant is known to have various pharmacological activities and is traditionally used in treatment but it lacks adequate scientific proof of this activity and constituents responsible for it. Wagner h, geyer b, kiso y, hikino h, rao gs 1986 coumestans as the main active principles of the liver drugs eclipta alba and wedella calendulaceae. There are also reports of clinical improvement in the treatment of infective hepatitis. Ethanolic extract of eclipta alba eeea was evaluated for memory enhancing activity using.
Dec 30, 2015 hepatoprotective effect of enicostemma littorale blume. Using the wellestablished animal model of concanavalin a. Abstract eclipta alba is a herb commonly found throughout india. Oct 29, 2014 an alcoholic extract of freshly collected eclipta alba exhibited dosedependent 62. Jul 30, 2009 the activity was assessed by studying the melanogenesis in resected skin, follicle count in the subcutis, skin thickness and surrogate markers in vehicle control and extract treated animals. Jun 20, 2018 eclipta alba false daisy is a herb that has traditional usage as a liver tonic in ayurveda. Hepatoprotective effects of eclipta alba on subcellular.
It is known in the three major forms of traditional medicinal systems in the indian subcontinent, namely, ayurveda, unani. The herbal composition of present invention comprises extract of andrographis paniculata. The present study was undertaken to study the hepato protective. Since the liver is involved in almost all biochemical processes and there are many different diseases that will affect it. It is whole plant of eclipta alba belonging to family compositae.
Comparative hepatoprotective activity of three phyllanthus. In indian systems of medicines herbal decoction of eclipta alba is used for the treatment of liver cirrhosis, infective hepatitis liver inflammation due to a viral infection, liver enlargement, and other related diseases of. Hepatoprotective activity of ethanolic extract of eclipta. Collect 250 ml of eclipta alba leaves juice, 50 ml. Jan 14, 2019 in vivo hepatoprotective activity of active fraction from ethanolic extract of eclipta alba leaves. Hepato protective activity of eclipta alba liver protective action phytochemical standardization hair growth promotion activity. The effect of agnps was studied against fourth instar larvae of filariasis vector, culex quinquefasciatus and malaria vector anopheles subpictus grass rajakumar and abdul. The study shows that hepatoprotective activity of ea is. Eclipta alba bhringraj benefits and usages ayurveda. The previous studies shows that hepatoprotective activity of eclipta alba is by regulating the levels of hepatic microsomal drug metabolizing enzymes saxena ak, et al. Eclipta alba extract was evaluated for its antifungal activity in in vitro and in vivo against sorghum fungal pathogens fusarium thapsinum, alternaria alternata, epicoccum sorghinum, and curvularia lunata. These herbal drugs have equivalent therapeutic value with the standards drug silymarin. Since the time of ayurveda till today bhringraj eclipta alba is a topnotch herb used in hair care industry.
Eclipta alba extract was evaluated for its antifungal activity in in vitro and in vivo against sorghum fungal. The methanolic extract of fresh leaves of the plant eclipta alba ea was known to produce hepatoprotective activity. Eclipta alba is being examined for its memory enhancing quality as it is traditionally used for this purpose. The current study aimed to investigate the hepatoprotective effect of wedelolactone, a major coumarin ingredient of eclipta prostrata l. Boerhaavia diffusa, eclipta alba, picrorrhiza kurroa, cichorium intybus and tinospora. In indian systems of medicines herbal decoction of eclipta alba. Hepatoprotective effect of enicostemma littorale blume. This has prompted the identification and development of ecofriendly greener alternatives.
Sitha institute of pharmaceutical sciences 2, hyderabad, andhra pradesh, india. Pharmacological activity and chemical constituents of ecliptaalba. In indian systems of medicines herbal decoction of eclipta alba is used for the treatment of liver cirrhosis, infective hepatitis liver inflammation due to a viral infection, liver enlargement, and other related diseases of liver and gall bladder 39. The effects observed were compared with a known hepatoprotective agent, silymarin. There was decreased activity of glucose6 phosphatase and fructose1,6bisphosphatase, and an increase in the activity of liver hexokinase. The activity was assessed by studying the melanogenesis in resected skin, follicle count in the subcutis, skin thickness and surrogate markers in vehicle control and extract treated animals. Screening of leaves and roots of eclipta alba for hepatoprotective activity v. Antibreast tumor activity of eclipta extract invitro and. It is a seminar on hepatoprotective drug authorstream presentation. There are three kinds or eclipta alba the whiteflowering, the yellowflowering, and the blackfruiting, but all three grow throughout india by marshes, rivers, and lakes or on the foothills of the himalayas.
Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats. Ea significantly counteracted ccl 4induced inhibition of the hepatic microsomal drug metabolising enzyme amidopyrine ndemethylase and membrane bound glucose 6phosphatase, but failed to reverse the very high degree of. Pharmacological activity and chemical constituents of. Hepatoprotective activity of ethanolic extract of eclipta alba in. The wide range of compounds showing antiulcer and hepatoprotective effect, among them flavonoids is most important. The maintenance of a healthy liver is vital to overall health of the human beings. Moreover, it is very important to study the specific phytochemical compounds responsible for this hepatoprotective effect. Liver disease is the major cause of serious health problem leading to morbidity and mortality worldwide and the problem has increased in search for hepatotherapeutic agents from plants. Eclipta alba extract with potential for hair growth. The wide range of compounds showing antiulcer and hepatoprotective effect. Fengmin xi, chuntong li, junling mi, zhijun wu, wansheng chen. The plant eclipta alba linn hassk family asteraceae has been mentioned in ancient texts to be a nervine tonic in addition to possessing hepatoprotective, hair growth promoting and antiaging properties. The objective of the present study was to evaluate the effect of eclipta alba l. Eclipta alba supplement health benefits, dosage, side.
The heptoprotective of the study confirmed the hepatoprotective activity of aqueous extracts of e. Evaluation of hepatorenal and haematological protection. This wonderful plant may be found as an erect or prostrate with many branches having roughly hair. In vivo hepatoprotective activity of active fraction from ethanolic extract of eclipta alba leaves. Lal 1, amit kumar 1, prashant kumar 2, kuldeep singh yadav 3 1 department of pharmacy, sagar inst. The most commonly used parameters to assess the hepatoprotective activity are morphological e. Haematological protective effect of raw extract and nano. Nov 10, 2019 in vivo hepatoprotective activity of active fraction from ethanolic extract of eclipta alba leaves. Eclipta alba extract with potential for hair growth promoting. Comparative study on hepatoprotective activity of aegle. Narendra kumar paliwal tutor in pharmacology, department of pharmacology, govt.
The hepatoprotective potential of the fraction prepared from alcoholic extract was studied. A major project report on evaluation of hepatoprotective activity of amoora rohituka submitted to rajiv gandhi proudyogiki vishwavidyalaya in partial fulfillment of the requirement for degree of master in pharmacy pharmacology, bhopal submitted by shailly malviya supervisor cosupervisor dr. Mar 21, 2017 since the time of ayurveda till today bhringraj eclipta alba is a topnotch herb used in hair care industry. It appears to have preliminary evidence to suggest hair growth promotion as potent as minoxidil and some antidiabetic effects as well as liver protection. There are no known side effects with this medicine in its regular dose. U 405 international journal of environmental sciences volume 2 no. Wo2011074001a2 a hepatoprotective herbal composition. Unscientific use of synthetic fungicides in plant disease management has environmental ramifications, such as disease resurgence and serious health problems due to their carcinogenicity. Hepatoprotective activity of eclipta alba is well described in literature 33, 3538. The present invention provides a herbal composition comprises potent liver specific herbs which improves the liver function and also helpful in cleaning the toxic accumulations and detoxifying poisons in liver.
Jaya raju, investigation of hepatoprotective activity of spondias pinnata, international journal of pharma sciences and research, vol. Plants free fulltext antifungal activity of eclipta alba. Hepatoprotective effect of wedelolactone against concanavalin. Indian journal of physiology and pharmacology, 45, 435441. It is regarded as a weed of ethnomedicinal significance. Tabassum n, agrawal ss 2004 hepatoprotective activity of eclipta alba hassk. Hepatoprotective effects of eclipta alba on subcellular levels in rats. Its effect on mitochondrial succinate dehydrogenase and adenosine 5 triphosphatase was not significant. Agrawal, hepatoprotective activity of emebelia ribes against paracetamol induced acute hepatocellular damage in mice, experimental medicine, 2003, vol. Read comparative hepatoprotective activity of three phyllanthus species, p. Antibreast tumor activity of eclipta extract invitro and invivo. Rajakumar and abdul rahuman 2011 investigated the larvicidal activity of synthesized agnps produced by aqueous extract of eclipta prostrata, a member of the asteraceae.
An alcoholic extract of freshly collected eclipta alba exhibited dosedependent 62. Hindi balari, bhangra, bhringraj, bhengra, mochkand, bhangaraiya. Aerial parts of eclipta alba are used traditionally for the treatment of several diseases of liver, skin and stomach. Similar hepatoprotective effects have also been reported in rabbits. Article received on 12012017 article revised on 03022017 article accepted on 25022017 description of eclipta alba linn. The protective effect of the plant against carbon tetrachlorideinduced acute liver dam age has been reported 3. Review on some medicinal plants with hepatoprotective.
The model used was carbon tetrachloride ccl 4 induced acute hepatotoxicity in albino rats. It is a weed which grows in tropical and subtropical regions all over the world. Bhringraj is a widely celebrated medicinal plant, especially in india, used singly or in combination with other herbs such as amala, shikaakai for making a vast range of hair care, hair rinse and conditioner products. Eclipta prostrata an overview sciencedirect topics. Evaluation of hepatorenal and haematological protection of ethanolic extract of eclipta alba in. Eclipta alba definition of eclipta alba by medical. Antibreast tumor activity of eclipta extract invitro and in. Hepatoprotective activity of ethanolic extract of eclipta alba in albino rats. Gujerati bhangro, dadhal, kalobhangro canarase ajagara, garagadasoppu, kadiggagaraga marathi bhangra. Mohammed ishaq 3 deccan school of pharmacy 1, hyderabad, andhra pradesh, india.
Hepatoprotective and cardiac inhibitory activities of. Liver weight and volume, biochemical estimations, such as measurement of transaminase activity, sgpt, scot, alkaline phosphatase, serum bilirubin, total serum proteins, albumin, globulin and prothrombin time, functional parameters, pentobarbitone. Phytochemical screening of methanolic extract and antibacterial activity of active principles of hepatoprotective herb, eclipta alba sunita dalala, sudhir k kataria b, kv sastry and svs ranac adepartment of biotechnology, kurukshetra university, kurukshetra6 119, haryana, india bdepartment of zoologybioscience, maharshi dayanand university. These findings suggest that methanol extract of eclipta alba may have potential as a hair growth promoter. Some study showed that hepatoprotective activity of the extract of e. Visited 467 times, 1 visits today downloads pdf downloads. Eightyone wistar albino rats were divided into four groups. Global journal of medical research 36 volume xiii issue vii version i year. Indigenous drugs are being constantly explored for this purpose.
The study was designed to evaluate the hepatoprotective activity of p. Ethnopharmacological significance of eclipta alba l. Evaluation of hepatorenal and haematological protection of. Antifungal activity of eclipta alba metabolites against. The acute toxicity studies have shown that like ea, fraction eaii also high safety margin. Hepatoprotective activity extensive research corroborates the hepatoprotective activity of eclipta alba. Massage you underfeetheel skin with eclipta alba juice regularly to cure this pain. Pdf hepatoprotective and curative effect of eclipta prostrata on. The hepatoprotective activity of olive oil and nigella. Kesharanjana, mochkand, bhangra plant introduction eclipta alba, the annual herbaceous plant, is also called as false daisy. Suresh kumar and mishra 2008 have also reported hepatoprotective effect of pergularia demia ethanol extract.
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